PHTY305 Lecture Notes - Lecture 6: External Validity, Internal Validity, Clinical Trial
Document Summary
Will the results help in caring for patients: does the intervention do more good than harm, weighing up the beneficial effects of intervention against subjective impressions of the cost and risks of intervention. I(cid:374)volves (cid:272)o(cid:374)sideratio(cid:374) of patie(cid:374)ts(cid:859) per(cid:272)eptio(cid:374)s of (cid:271)e(cid:374)efits a(cid:374)d (cid:272)osts. About the study design & conduct (internal validity) Was the assignment of patients to treatments randomized: process should be explained in detail, can be stratified to get equal groups. Intervention described in detail: was there allocation concealment, 1b. Aside from experimental intervention, were the groups treated equally: replicate study, focus of intervention, who delivered it, how often treatment received, setting, contamination and co intervention avoided, 2b. Were all patients who entered the trial properly accounted for at its conclusion: were drop outs reported, reasons, how analysis of drop outs was performed should be reported, add up all the numbers, 3. If no drop outs, this should also be noted. Comparing interventions or correlations: 2 or more treatment outcomes.
