CHEM1101 Lecture Notes - Lecture 1: Ammonium Chloride, Medicinal Chemistry, Inorganic Chemistry
Organic Chemistry text - Jonathan Claydon, Nick Greeves and Stuart warren, Oxford University
press, 2nd ed., 2012
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Bring molecular model kit
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Chapter 30: solving molecular structures
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Chapter 22: the chemistry of organic compounds
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Chapter 24: chemistry of alkenes and alkynes
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Chapter 28: benzene and derivatives
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Chapter 23: Stoichiometry
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Regular textbook: chapters
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Resources
Only found in 1 spot
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Put on spearheads to make them toxic
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Angina-like chest pain
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Asthma-like breathing difficulties
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Tachycardia,
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Unstable blood pressure
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Haemolysis (destruction of red blood cells)
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Rapid onset, death follows in minutes
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Symptoms
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Molecular formula: C₁₂₉H₂₂₃N₃O₅₄
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Molecular weight: 2680.13 amu
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Stereochemical elements: 71 stereogenic centres - shape
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So many isomers that there is not enough carbon on earth to construct it
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The plant only produces one specific isomer
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The traceable lines represent carbon - carbon lines
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Points on lines represent carbon atoms
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Has more than one functional group (many, which interact with each other)
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Why does this this toxin cause these things? What is its chemical stricture?
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Palytoxin - found in a moss and was thought to be used as biological warfare
Structure - reactions - mechanism (intimate connection)
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Historical definition: materials obtained from living things
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Organic compounds = non-physical inner force or energy that gives life
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Vs inorganic chemistry: materials derived from rocks and mineral
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Obtained urea by treating silver isocyan ate with ammonium chloride
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This debunked the theory that organic compounds can only be obtained from living
things - due to inner force
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Over 90% of the almost 92 million (as of 2015) known compounds are organic (goes up
by about 5 million annually)
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Happens all the time in medicinal chemistry - foresee that a molecule might have
desirable properties
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Understanding the general structures and applying them to all these molecules
(functional groups) helps us to draw conclusions on the behaviour of the compound
without having to go make it
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Father or organic chemistry: Friedrich Wöhler
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Modern definition: the chemistry of carbon based compounds
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Very important: medicines, DNA, RNA, spider webs, polypeptides, Kevlar, agricultural products
(food) rely on organic pesticides, fuels, etc. are all organic
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Organic chemistry is a creative science
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Organic chemistry:
Structure of Carbon
Lecture 1 - Introduction to Organic Chemistry
03 March 2017
11:06
CHEM1101 Page 1
