BM1022 Lecture Notes - Lecture 24: Suppository, Pharmacology, Pharmaceutics
Document Summary
Most reactions are equilibrium reactions so if some product is removed (ie by absorption) then ________ will be created. Strong acids and bases are both corrosive / burn tissue. Therefore absorbed better in stomach, taken after meal to increase residence time (also irritate stomach). Strongly acidic/basic drugs not well absorbed as highly ionized. Factors affecting absorption of drugs: pka and environmental ph (ionisation). Include diagram of passive diffusion like p147 of text. Molecules need to be un-ionized (ie lipophilic) to cross membranes. Some drugs are transported by transport proteins (example: oatp1a2, oct3, Limited absorption due to thick mucous, low junctions, short retention time. Food increases retention time and splanchn tablets with meal including absorption of ac. , low sa, tight intracellular chnic blood flow so taking f acidic drugs. vironment. age by low ph. ch. High sa, higher ph longer residence, higher blood flow. Absorption from small intestine is delayed with food.
