BIOM30001 Lecture Notes - Lecture 26: Phantom Limb, Phantom Pain, Cannabinoid Receptor Type 2
Document Summary
Value of preclinical testing of drugs in animal models. In 5% (~1 million people), pain has a significant impact on function and quality of life. Complex medical condition: may lead to secondary physical consequences with major impact. Changes to psyche, sleep patterns, appetite, behaviours and thoughts. Social and psychological environments contribute to perception of pain. Malignant ulcers bone metastases; liver capsule distension or inflammation, arthritis. Deep abdominal or chest masses; intestinal, biliary colic. "pins and needles", tingling, burning, shooting; allodynia; phantom pain. Visceral pain is aching - diffuse pain. e. g. inflamed appendix. But when this contacts peritoneum you get pain from deep somatic pain (localised) Neuropathic: pain continues after injury. e. g. diabetes patients have peripheral neuropathy in lower limbs. People with amputations have phantom limbs which can experience chronic pain due to neuroma. Nerves severed/traumatised-->sprout-->upregulate na channels-->cross talk between nerves-->ectopic activation. Chronic pain is a dysfunctional state of the nervous system. Produces continual pain impulses to spinal cord and brain.
