BIOM30002 Lecture Notes - Lecture 31: Neurodegeneration, Language Disorder, Histology
Document Summary
31: may 19 - intro to neurodegeneration: clinical- neuroanatomical relationships. Classic view: make a model e. g. introduce pathogen into mouse. Biochemistry: can identify a model neuron type and hope it applies to other neuron types. Can"t see language disorder in a mouse, but can model memory loss (using hippocampus) - mouse model is limited by definition. Animals can only model specific aspects of the biochemistry or behaviour of a neurodegeneration because they lack many of the brain regions that are affected by human disease - cannot comprehensively model the human phenotype. Neuro-degeneration what causes it? e. g. polio: catch the virus single pathogenic agent get the pathology: pathogenic agent causes the disease. Degenerative disease are different because there is no single aetiological agent. Confluence of enough risk factors is enough to precipitate the event, and once the event is underway, it has its own momentum. M2m page 1 underway, it has its own momentum.
