CEDB20003 Lecture Notes - Lecture 14: Centromere, Sister Chromatids, Nuclear Membrane

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An organism is buil from cell proliferation and growth. G1 phase: mainly attaining volume from having divided. S phase: where the dna is replicated, synthesis of dna. G2 phase: growth or gap phase 2. M phase: where all the division occurs. The proteins cyclin and cyclin-dependent kinase are key to cell cycle transitions. The cell cycle four phases this leads to progression of the phases different cyclins activate different cdk"s. The cdk"s have different downstream targets that they activate. Displacement of an interference loop in the cdk proteins via cyclins promote activation of the this interphase loop inactivates the kinase by activating further by adding to the interference loop you fully activate it. Cyclin activate cdks via kinases and feedback loops. When its not needed ubiquiting is tagged. Mitotic and cytokinesis protein complexes drive through the different cycles. Cdk will get us from one phase to the next.

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