CEDB20003 Lecture 21: L21
13 Aug 2018
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Document Summary
Cell survival signaling (pi3-akt) ser/thre receptor signaling (tgf -smads) Apoptosis extrinsic pathway regulated by decoy receptors and intracellular blocking proteins can also recruit intrinsic pathway there are several pathways which can activate apoptosis. Mitochondiral membrane permeability is due to bcl2 protein. Mitochondria can initiate the intrinsic pathway by recognising stress. Bcl2 channels which will adapt to the apoptosome which will then activate the caspase cascade and lead to cell death. Anti-apoptotic proteins (bcl2) bind & inactivate bh123 pro-apoptotic proteins. Pro-apoptotic bh3-only protein (bad/bim) transcription; inhibits bcl2 (anti- There are 3 main types of bcl2 families (a) have characteristic all 4 bcl ranges. Keep the channels closed (b) the bh123 proteins lacking the bh4. Proteins that tend to sit on the membrane of the mitochondria forming channels allowing cytochrome c to be excreted out (c) The good guys have all 4 bh domains which are protein interaction domains.
