MEDI40004 Lecture Notes - Lecture 3: Membrane Potential, Nav1.1, Valproate
26 Jan 2021
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Document Summary
73% of epilepsy genes -> can be caused from various type of reason. Ion channels in generic epilepsy precision based work flow identified mutated ion channels functional analysis in vitro. Mice display eeg spiking how spikes that can be recorded and quantified. Hcn1 causes channels to remain open at depolarised membrane potential. Cation leaky channels depolarisation therefore in this case, must more depolarisation this maybe the reason of the depolarisation (higher threshold) always depolarisation. Her system has adapted to the abnormal depolarsation, her high threshold is higher. Ki mouse is learning ability is similar to wt at short term but long-term ki decreases. Worked with high doses valproate decreases seizures and decreases the. Lamotrigine increases the seizers and spiked the frequency frequency. Present with prolonged seizures with fever at 2 years of age. Excitatory nav1. 2 inhibitory if the inh absent or decreased, exc will increase. Increase the function of nav1. 1 and causes the increase of hm1a which increases inh.
