NEUR30002 Lecture Notes - Lecture 15: Syntaxin, The Sequence, Endosome

• School: University of Melbourne
• Department: Neuroscience
• Course: NEUR30002
• Professor: Angelina Fong

Document Summary

* despite the presence of an sm protein (munc 18), phospholipid mixing and vesicle fusion does not occur in the absence of calcium. * synaptotagmin-1 and complexin act together to provide: A spanner in the works of the snare machinery. It is due to the presence of two very critical proteins which are more or less specific to neuronal terminals (not absolutely specific). They also act as a clamp and they act as the spanner in the works on of the snare assembly. What"s the diffe(cid:396)e(cid:374)(cid:272)e (cid:271)et(cid:449)ee(cid:374) (cid:271)ei(cid:374)g tethe(cid:396)ed i. e. ha(cid:448)i(cid:374)g a. When the vesicle is docked/tethered there are thought to be 3 snare complexes between that docked vesicle and the membrane. * the idea is that you first form a snare complex. By virtue of having synaptobrevin, these vesicles (cid:272)a(cid:374) o(cid:374)l(cid:455) fo(cid:396)(cid:373) a nare (cid:272)o(cid:373)ple(cid:454) (cid:449)ith the s(cid:455)(cid:374)apti(cid:272) te(cid:396)(cid:373)i(cid:374)al (cid:271)e(cid:272)ause it"s the o(cid:374)l(cid:455) o(cid:374)e that has the complimentary snare proteins.