PHYS30005 Lecture Notes - Lecture 3: Glycogen Synthase, Carbohydrate Metabolism, Exercise Intensity
25 Jul 2018
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Document Summary
Need a continuous supply of atp (from cho and lipid metabolism) Substrate stores of plasma, liver and muscle glucose replenished. Regulation of insulin secretion by glucose and amino acids. Meal increase in plasma glucose, reaches pancreas, beta cells take up glucose, ca2+ influx and insulin secreted. Increases muscle glucose uptake: activates glycogen synthase. Increases tg storage and inhibits adipose tissue lipolysis. Complex pathway but just remember lots of receptors and ends up with glut4 vesicles (sensitive glucose transporter to membrane to increase glucose uptake) Glucagon: stimulates glycogenolysis = when glucose levels are low, glucagon is secreted from alpha-cells of pancreas to signal the release of glucose from the liver, change in metabolism of glucose signals glucagon which signals glucose secretion (cycle). Stimulates breakdown of glycogen (from pancreas to liver) (glycogen glucose) in liver. Stimulates breakdown of glycogen (from pancreas to liver) (glucose glycogen) in liver. Stimulates glucose uptake from blood to tissue cells.
