PHYS30005 Lecture Notes - Lecture 21: Skeletal Muscle, Muscle Hypertrophy, Muscle Atrophy

• School: University of Melbourne
• Department: Physiology
• Course: PHYS30005
• Professor: Professor

Document Summary

Lecture 21 the role of inflammation in skeletal muscle maintenance. Heat, redness, swelling, pain, loss of function. Chronic: associated with muscle atrophy, aging, mets (metabolic syndrome, myopathies. Acute: associated with muscle hypertrophy, following exercise, necessary for muscle gains. Inflammatory responsive mediators: neutrophils, monocytes & macrophages, signalling molecules: cytokines & chemokines. Muscle damage caused by: mechanical stretch, bacterial products, or acute muscle injury. Release of immune cells (macrophages, neutrophils, monocytes) released in tissue and in circulation. Activation of immune cells within muscle -> activates satellite cells (important for muscle repair. Becomes chronic if mediation isn"t properly regulated. Satellite cell repair is needed for muscles to repair from injury. In response to muscle trauma, satellite cells become activated -> proliferate to damaged site -> differentiate into myoblasts -> fuse into myofibers -> stimulates myofiber regeneration. Main time frame for immune cell involvement following a stress insult is 0-14 days. 3 main phases: (occur within 30 day time frame: destruction.