PSYC20006 Lecture Notes - Lecture 17: Haplotype, Alanine, Adenine

• School: University of Melbourne
• Department: Psychology
• Course: PSYC20006
• Professor: Stefan Bode

Document Summary

Individual"s genotype at snp is determined by the 2 alleles on the. 2 couples of the chromosome: slightly different for xz & y chromosomes on genetic males. Individual"s phenotype: presence, absence or value of a trait of interest: e. g. psychological diagnosis (binary), parenting style (categorical), iq (quantitative) Insertion-deletion: bases added or missing: block-substitution: multiple bases substituted, copy-number: sequence of bases repeated 1 or more times. Inversion: bases replaced with reversed sequence from other strand: mutation: rare, <1% alleles in population, polymorphism: common, >1% alleles in population. If 1 twin has trait/disorder, does the other: monozygotic (mz) twins inherit identical genetic material, dizygotic (dz) twins share ~ genetic inheritance, higher accordance in mz pairs than dz pairs, suggests genetic component, assuming equal environment. Genetic linkage: co-inheritance in pedigrees of phenotype with directly genotyped genetic markers with known locations on genome, suggests disease-influencing genetic locus physically close to marker, e. g.