PSYC30018 Lecture Notes - Spring 2018 Lecture 18 - Cognitive therapy, Pharmacotherapy, Clinical trial
Document Summary
Higher diagnosis rate in females than in males. Leading cause of years lived with disability: current treatments. 40% achieve remission with first treatment; 10% become resistant to treatment over time offered the option of ect. 4 medication failures predict depression relapse after ect. Deep brain stimulation as an treatment option for those who do not respond to ect: new treatments difficulties. Dsm defines disorders by behavioural presentation, not pathology. Few animal models for representing depression difficult to design new interventions: depression circuits, theoretical constructs, structural lesion correlation studies. Significant reductions in volume in certain cortical regions frontal pole, caudate and hippocampus. Difficulties with sleeping, less aerobic exercise (negative impact on neurogenesis) are consequences of depression which could have caused structural changes as well. Meta-analysis of 1728 mdd and 7199 controls from 15 studies the hippocampus is the region which most consistently shows sub-cortical volume changes: functional changes.
