BIO1011 Lecture Notes - Lecture 6: Liposome, Cell Signaling, Membrane Protein

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Lecture 6 - Cells and Membranes
Living things
Are organised into cells
Prokaryotes and eukaryotes
Must maintain an internal environment
Without barriers, life’s components would simply diffuse away
Prokaryote vs. Eukaryote
Prokaryotes
Generally smaller
Bacteria are usually prokaryotes
Nucleoid (floating DNA)
Capsule
Circular DNA
Cell wall and cell membrane
Eukaryotes
Usually larger
Membrane bound nucleus
Complex endomembranes
Linear DNA
Membrane-bound organelles
Plants also have cell wall and chloroplasts
Overview of membranes
Water is polar
Oxygen molecule tends to drag electrons away from the hydrogen
Main component of membrane is a phospholipid
Amphipathic molecule
Head is hydrophilic (charged), tail is hydrophobic (uncharged)
The phospholipids arrange themselves into a bilayer sheet, a liposome or a
micelle
Initially a liposome that is a ring of tail-facing phospholipids containing
water in the centre
Membrane components - fluid mosaic model
Fluid because phospholipids are moving around, not rigid
Proteins embedded in the membrane is the mosaic component
Membrane structure & function
Diverse phospholipids comprise the bilayer (omega 3 vs. omega 6 fatty acids
are used in a ratio to make up the bilayer)
Other lipid components
Glycolipids - fatty acid with sugar (hydrophilic) attached used for cell-
cell signalling
Cholesterol - increases fluidity (at low temps) reduces fluidity - makes
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Document Summary

Without barriers, life"s components would simply diffuse away. Plants also have cell wall and chloroplasts. Main component of membrane is a phospholipid. Oxygen molecule tends to drag electrons away from the hydrogen. Head is hydrophilic (charged), tail is hydrophobic (uncharged) The phospholipids arrange themselves into a bilayer sheet, a liposome or a micelle. Initially a liposome that is a ring of tail-facing phospholipids containing water in the centre. Fluid because phospholipids are moving around, not rigid. Proteins embedded in the membrane is the mosaic component. Diverse phospholipids comprise the bilayer (omega 3 vs. omega 6 fatty acids. Other lipid components are used in a ratio to make up the bilayer) Glycolipids - fatty acid with sugar (hydrophilic) attached used for cell- cell signalling. Cholesterol - increases fluidity (at low temps) reduces fluidity - makes stable (at high temps) Unsaturated tails stick out and pull membrane apart somewhat.

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