GRS4101 Lecture Notes - Lecture 1: Sex Steroid, Ovarian Follicle, Anabolic Steroid
24 Jul 2018
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Hormones: reproductive messengers (chemical messengers in blood and interstitial fluid) Hormones travel in blood to target tissues: work slowly (seconds to minutes), long acting, widespread effects, has to be cleared from blood. Alter cellular activity of the target cell: changes its function, increases gene function. Bind to specific receptors in nucleus (steroids) or on cell surface of target cells (peptides, proteins) Act at very low concentrations, but have very large effects (tough to measure hormone levels in blood. Hormones can act at variable distances from the source organs cells. Endocrine: secreted by organ or cell by blood to target cell e. g. lh. Paracrine: released from source cell, via interstitial fluid, to adjacent target cell e. g. leydig cells. Autocrine: cell produces hormone also contains the receptors for said hormone e. g. oestrogen. Exocrine: hormones enter into duct system e. g. oestrogen in ovarian follicle. All sy(cid:374)thesised f(cid:396)o(cid:373) choleste(cid:396)ol o(cid:396)igi(cid:374): all do(cid:374)"t sto(cid:396)e the ho(cid:396)(cid:373)o(cid:374)e, is sy(cid:374)thesised as (cid:396)e(cid:395)ui(cid:396)ed.
