PHY3181 Lecture 2: Male Hormones
10 Feb 2019
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Document Summary
Two main functions of the testis: spermatogenesis. Contains sertoli cells + germ cells: hormone synthesis + secretion. Occurs in interstitium - testicular interstitial tissue: contains a collection of cells that sit outside seminiferous tubules, highly vascular, well-developed lymphatics, loose connective tissue + macrophages. Leydig cells: powerhouse of making male steroids, responsible for steroidogenesis where testosterone is made, responsive to lh has lh receptors, 2 way paracrine interactions with sertoli cells. Autocrine = signalling to the same cell type. Cholesterol via blood supply, acts directly on leydig cells: l cells responding to lh receptor activation (receptors on l cell, lh comes from blood via anterior pituitary to act on receptor, lh receptors releases camp into the. Sertoli cells: then converted to other steroids like. Relationship between lh and testosterone release from leydig cells: gnrh and lh are pulsatile, therefore, testosterone is pulsatile, testosterone is quite variable due to pulsatility. Not constructed of amino acids like protein hormones.
