PSY2071 Lecture Notes - Lecture 6: Single-Nucleotide Polymorphism, Dsm-5, Chromosome
16 Jun 2018
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Week 6 continued
Gene behaviour associations in development
Part 2
How are neuro-developmental disorders diagnosed
1. Problem behaviours flagged by caregiver
2. GP gives referral to psychologist
3. Child psychologist assesses child on DSM-5 criteria and takes into account all the
other information provided
Assisting people with neuro-developmental disorders requires understanding of the whole
system: genes - brain - environment - behaviour
Abnormal behaviour reflects abnormal brain function.
By studying gene- behaviour relationships in Neuro-developmental disorders that have a
strong genetic origin we can:
-Improve Diagnostic Reliability
-Reduce time to diagnosis
-Tease apart the causes of problem behaviours
-Develop sensitive & appropriate treatment options
Genes, Alleles and SNPs
What are genes?
-Distinct sequence of DNA forming part of a chromosome, which is the blueprint for a
protein
What are alleles?
-Alleles are alternative forms (variants) of a gene
What are single nucleotide polymorphisms SNPs
-A variation in a single nucleotide that occurs at a specific point in the genome
find more resources at oneclass.com
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Document Summary
How are neuro-developmental disorders diagnosed: problem behaviours agged by caregiver, gp gives referral to psychologist, child psychologist assesses child on dsm-5 criteria and takes into account all the other information provided. Assisting people with neuro-developmental disorders requires understanding of the whole system: genes - brain - environment - behaviour. By studying gene- behaviour relationships in neuro-developmental disorders that have a strong genetic origin we can: Tease apart the causes of problem behaviours. Distinct sequence of dna forming part of a chromosome, which is the blueprint for a protein. Alleles are alternative forms (variants) of a gene. A variation in a single nucleotide that occurs at a speci c point in the genome. The hypothesis helps us to understand disease whose genetic contribution is believed to come from multiple genes simultaneously, polygenic disorders, such as autism. This hypothesis states that if a disorder is of genetic origins, and has a prevalence of.
