BVB212 Lecture Notes - Lecture 11: Budesonide, Beclometasone Dipropionate, Leukotriene
Document Summary
Lung disease: obstructive airway, caused by environmental, genetic and behavioural factors, preventable but difficult to treat. Loss of functional lung tissue (low gas exchange) Treatment: remove irritant, glucocorticoids (anti-inflammatory, bronchodilators, b2-adrenoceptor agonists, eg. salbutamol, terbutaline, salmeterol, clenbuterol, formoterol, moa, direct action on smooth muscle to relax airways, also antagonists of bronchoconstrictors. Increase mucus clearance: adverse effects, cardiac dysrhythmia, xanthine drugs, eg. caffeine, theobromine, theophylline (oral), aminophylline (iv, moa, relax smooth muscle, adenosine receptor antagonist. Stimulate the cns: adverse effects, cardiac dysrhythmia, antitussives (cough suppressants, codeine, dextromethorphan. Pathogenesis: activation of th2 lymphocytes in the bronchial mucosa promotes cytokine production, promotes ige production. Acute phase: respond to allergen, spasm of bronchial smooth muscle, release of histamine. Influx of th2 lymphocytes: progressive damage and loss of epithelium, worsening of bronchial hyper-reactivity. Increased airway resistance: narrowing of airway, decreased alveolar ventilation, decreased ability for airway relaxation to occur.
