BVB301 Lecture Notes - Lecture 9: Hox Gene, Neural Development, Neurogenesis
Document Summary
Blastocoel formation (hollow cavity with cells on the outer) Cells need to have basic arrangement on axis. Multipotent: has potential to give rise to any cell in the body. Move it: positive inference ie. moving a cell or gene to a different spot to see if it still has its function. Lose it: completely remove the cell or gene and see what happens. Assay: look for signals that induce the formation of an ectopic axis. Chordin (is a gene that gives rise to a protein) is expressed in the dorsal lip - if you do a loss of function (take its function away), ventralised! Bmp4 = effective inhibitor of bmp (no skin), nervous system (mesoderm is responsible for this) Bmp and wnt inhibitors to anteriorize neural tube, cereberus dickkopf. Mesoderm - a bit of wnt, but nothing hectic. Dkk1 is a wnt inhibitor required for head induction. Retinoic acid: a regulator of a-p patterning, helps decide what is posterior.
