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BABS1201 Lecture Notes - Lecture 10: Pyruvic Acid, Atp Synthase, Symbiogenesis

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UNSW, UNSW Sydney
Department
Biotechnology & Biomolecular Sciences
Course
BABS1201
Professor
All

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Document Summary

Glucose + o2 h20 + co2 + chemical energy (atp) Glycolysis - breakdown of a molecule of glucose into two molecules of pyruvate. Investment stage: two molecules of atp are consumed for each molecule of glucose, glucose is converted to fructose-1,6-bisphosphate, fructose-1,6 is cleaved into two 3-carbon units of glyceraldehyde-3-phosphate. Harvesting stage: four molecules of atp and two molecules of nadh are gained from each initial molecule of glucose, this atp is a result of substrate-level phosphorylation, glyceraldehyde-3-phosphate is oxidised to pyruvate. Tca cycle: generates the reducing agents nadh and fadh2 for electron transport chain function, eight enzymes completely oxidise acetyl-coenzyme a, acetyl-coa gets oxidised and reduces, nad* to nadh, fad to fadh2, carbon dioxide as a waste by product. When cytochrome reductase recieves electrons it gets oxidised by oxygen (high electronegativity: oxygen plus electrons combines with hydrogen ions to make h2o.

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Related Questions

1)Pyruvate is one of the products of glycolysis that can be used by aerobic organisms to extract additional energy. Explain what happens to pyruvate after glycolysis, name the multi-enzyme complex that catalyzes this reaction, and name the cycle that the product feeds into.

2)Suppose you start with 1 molecule of glucose and go through glycolysis to produce 2 molecules of pyruvate. These 2 molecules of pyruvate are then converted into acetyl CoA which then go through the TCA cycle. Theoretically, how many total ATP can be formed through this process? (Account for NADH/FADH2 produced). Show where each molecule of ATP is generated from.

3)Name the five types of membrane-bound electron carriers. All of the redox centers within the respiratory chain that accept and donate electrons are prosthetic groups except which?

4)Peroxisomes are the site of what? What properties do peroxisomes share with mitochondria?

Which of the following is not a net product of the citric acid cycle for each molecule of pyruvate generated in glycolysis?

Select one:

a. 1 ATP (GTP)

b. 1 acetyl coA

c. 3 NADH

d. 1 FADH2

Question 2

Which of the following is NOT an end product for an acetyl group that enters the citric acid cycle?

Select one:

a. ATP

b. NADH

c. FADH2

d. oxaloacetate

Question 3

Once they have been processed through the citric acid cycle, the acetyl-CoA molecules from a single glucose molecule produce:

Select one:

a. 2 ATP, 6 NADH, 4 CO2.

b. 6 NADH, 6 GTP.

c. 6 FADH2, 2 ATP, 6 CO2.

d. 6 GTP, 6 FADH2.

e. 4 CO2, 6 FADH2, 2 ATP.

Question 4

The products of the citric acid cycle breaking down 2 acetyl-CoA include 2 ATP (converted from GTP), 6 NADH and 2 FADH2.

Select one:

True

False

1. Integrated metabolism

A. A molecule of glucose that you eat can eventually be transformed into part of a fatty acid that you store. Circle the pathways/cycles below that are part of this overall flow of carbon atoms. Cross out any that are not.

Gluconeogenesis, beta-oxidation, citric acid cycle, glycolysis, urea cycle, fatty acid synthesis

B. Trace the metabolic path of this glucose molecule through the enzymes it encounters along the way to being made into fat. Write all the enzymes in the list below into the proper places in the figure below. If the enzyme is not used, write its name in a “not used" column. If it is used, write the enzyme in the order that the carbon atoms from glucose encounter the enzymes.

Pyruvate dehydrogenase, fumarase, aldolase, lactate dehydrogenase, pyruvate kinase, acetyl CoA carboxylase, fatty acid synthase, hexokinase, carnitine acyltransferase, ATP synthase

B. What is the minimum number of glucose molecules that would be necessary to be the carbon source for synthesis of a 16-carbon fatty acid through this pathway?

C. How many net glucose can be made from one molecule of a 16-carbon fatty acid?

2. Describe each cycle/transport system (compounds, compartments, tissues) and explain its purpose:

A. citrate transport system

B. Cori cycle

C. glucose/alanine cycle

3.

Explain the logic of these pathway regulations:

A. Phosphofructokinase, not hexokinase, is the main regulation site of glycolysis.

B. SuccinylCoA inhibits the entry of acetyl CoA into the citric acid cycle.

C. NADH inhibits pyruvate dehydrogenase.

D. Citrate inhibits the citric acid cycle and activates acetyl-CoA carboxylase.

E. Insulin leads to activation of glycogen synthase.