BIOM2071 Lecture Notes - Lecture 5: Perinatal Mortality, Tight Junction, Enterocyte
Document Summary
Impact of nutrients and drugs on foetal development. Pregnancy stats: births: 280,000/yr, maternal age: 30yrs, first-time mothers: 42, preterm: 8, post-term: 0. 8, perinatal death: 9. 3 per 1000 births, 1/6 couples have difficulty conceiving. Micronutrients and trace elements: healthy balanced diet should provide all necessary vitamins and minerals, but extra. Influence maternal, paternal and foetal health nutritional demands of pregnancy may make supplementation advisable: often dietary intake relatively poor habits continue during preconception and early gestational period. Conception (weeks 0-2): nutrients/drugs transferred into luminal secretions of fallopian tube and uterine cavity where ovum and blastocyst mast pass (drugs can kill but not cause congenital malformations as no differentiation between organ cells) A: large sample space with no proven direct harmful effects or increased malformation rates. B: limited sample space but no proven direct harmful effects or increased malformation rates. C: suspected of causing harmful effects, but may be reversible and/or no malformations in. B2: inadequate but no evidence of foetal damage.
