PCOL2605 Lecture Notes - Lecture 6: Spray Drying, Electrostatic Precipitator, Bulk Density
23 Oct 2018
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Aerodynamic diameter the diameter of a unit-density sphere which has the same sedimentation velocity as the particle of interest. Fine particle mass (or fine particle fraction): mass (or % mass) of fine particles in the aerosol. Mass (or % mass) of particles < 5 m in the aerosol. Deposition mechanisms impaction, sedimentation, diffusion, electrostatic precipitation and interception. Do(cid:374)"t wa(cid:374)t a(cid:374)y particles deposited in mouth. The diameter of a unit-density sphere which has the same sedimentation velocity as the particle of interest. Problems: amorphous materials, wide particle size distribution. Whole idea of using supercritical fluid is to use it for a solvent for extraction and to make particles. Dissolve and spray into container with scf co it will cause precipitation of drug out of the alcohol. If you (cid:272)a(cid:374) use a the(cid:374) use it (cid:271)ut if you (cid:272)a(cid:374)"t use b. Lactose as a carrier: particle size, shape, surface roughness, crystallinity (and amorphous content), polymorphism, fine content.
