PHSI3010 Lecture Notes - Lecture 9: Endocrine System, Monosomy, Trisomy
16 Mar 2019
School
Department
Course
Professor
Document Summary
Hormonal control of female reproduction: early to mid-follicular phase, late follicular phase & ovulation, early to mid luteal phase. Low levels of oestrogen start negative feedback to gnrh, Oestrogen promotes more oestrogen secretion by the follicle. Rising levels of oestrogen plus increasing progesterone cause lh surge. Combined oestrogen & progesterone shut off fsh and. Corpus luteum spontaneously dies after ~12 days if. Pregnancy does not occur: late luteal phase. Oestrogen & progesterone fall when corpus luteum dies. Gonadotrophins start follicular development for new cycle >>>>>>>>>>>>>> Receptivity of uterus to blastocyst implantation: pre-receptive phase. Epithelium has long apical microvilli, thick glycocalyx, -ve charge impairs attachment: receptive phase. *glycocalyx thins close apposition of blastocyst to uterus. Focal adhesions: provide structural link between ecm and actin cytoskeleton, central site for signal transduction regulating various. Tight junctions biological processes: provide a barrier to movement of substances across epithelium. Changes in signalling molecules during acquisition of uterine receptivity.
