PHSI3010 Lecture Notes - Lecture 20: Lateral Plate Mesoderm, Autocrine Signalling, Cell Migration
11 May 2019
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Lecture 20 (w10-1): lateral plate mesoderm osteogenesis/limb formation. Fsh, estrogen, growth hormone, insulin, pth, vitamin d. Bone mineral: give bone its tensile strength, type i, lamellar vs woven bone, alkaline phosphatase, proteoglycans, gfs in bone matrix, ca & p as hydroxyapatite, compressive strength. Skeletal embryogenesis: skeletal system- mainly cartilage & bone, osteochondral cells derived from various areas of mesoderm, 1st obv sign of skeletal development: condensation of mesenchymal cells at specific spaces (these locations become future skeletal locations) To describe the specific transcription factors and target cells involved in limb bud. In lateral plate mesoderm- we achieve: chondrocytes & osteoblasts: directional growth of skeleton, at apical ectoderm ridge, cells receive a message: fgf10- first signal for initiation of limb bud development, chondroblasts begin the process. 3beta in the active state, resulting in proteasomal degredation or beta-catenin (b) active wnt signalling, with lrp5/6 engaging in receptor complex after wnt binding, disruption of.
