300850 Lecture Notes - Lecture 11: Ulcerative Colitis, Helicobacter Pylori, Colorectal Cancer
Document Summary
Peptic ulcers types, locations, causes, role of h2 receptor antagonists: gastric ulcers > forms in the lining of the stomach, duodenal ulcers > forms in the upper small intestine. Causes include: helicobacter pylori (bacteria, frequent use of nsaids (non-steroidal anti-inflammatory drugs), e. g. aspirin, al(cid:272)ohol, hcl se(cid:272)retio(cid:374), a(cid:374)d a(cid:374)(cid:455)thi(cid:374)g that i(cid:373)pairs i(cid:374)hi(cid:271)itor(cid:455) (cid:373)e(cid:272)ha(cid:374)is(cid:373)s, as it(cid:859)s selfdigesting the lining of the stomach. The(cid:455)(cid:859)re all (cid:272)ausi(cid:374)g loss i(cid:374) epitheliu(cid:373) > decreasing mucous secretion. The h2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. Involves the colon and rectum (always involved). There are periods of flare (active inflammation) and remission (no inflammation). Diffuse inflammation with ulceration, where a long length of it is affected. When the rectu(cid:373) is i(cid:374)fla(cid:373)ed, it(cid:859)s (cid:374)ot a(cid:271)le to store its (cid:272)o(cid:374)te(cid:374)ts a(cid:374)d (cid:272)a(cid:374)(cid:374)ot disti(cid:374)guish gas from liquid > can lead to anxiety (constantly urge of go to the bathroom).
