300889 Lecture Notes - Lecture 12: Platelet-Derived Growth Factor, Cardiac Output, Thrombus
Document Summary
Smooth muscle cells: pdgf & other growth factors proliferation. Platelets: activate smooth muscle, promote thrombus formation. Pathogenesis summary: proliferation smooth muscle cells, proliferation macrophages, connective tissue laid down. Essential hypertension: sustained elevation, no obvious cause, majority of all hypertension, normal range tends to be. 100-140 systolic: will always be some outside this range, that is still normal!! Risk factors: family history, age, salt intake, obesity, excess sympathetic activity. Sodium retention: sv x hr = co, bp = co x pvr, positive correlation between body na & bp in some (not all) hypertensive. Impaired na excretion retention blood volume expansion increased cardiac output: raised cellular sodium prevents calcium transport out of smooth muscle cell raised pvr. Sympathetic activity: sympathetic activity influences co and pvr. Increased activity elevates pvr & causes volume expansion: renin plasma levels are raised in only a small number, many respond to ace inhibitors. Management: attend to risk factors, reduce peripheral vascular resistance.
