300905 Lecture Notes - Lecture 56: Multiple Sclerosis, Marburg Acute Multiple Sclerosis, Balo Concentric Sclerosis
Document Summary
Lecture 56- four types of ms: clinically isolated syndrome (cis, relapsing-remitting ms (rrms, primary progressive ms (ppms, secondary progressive ms (spms) Relapsing-remitting ms is characterized by unpredictable relapses followed by periods of months to years of relative quiet (remission) with no new signs of disease activity. Deficits that occur during attacks may either resolve or leave problems, the latter in about 40% of attacks and being more common the longer a person has had the disease. This describes the initial course of 80% of individuals with ms. The relapsing-remitting subtype usually begins with a clinically isolated syndrome (cis). In cis, a person has an attack suggestive of demyelination, but does not fulfill the criteria for multiple sclerosis. 30 to 70% of persons who experience cis, later develop ms. Primary progressive ms occurs in approximately 10 20% of individuals, with no remission after the initial symptoms.