300905 Lecture Notes - Lecture 59: Hla-C, Coiled Coil, Mhc Class I

• School: UWS
• Department: University of Western Sydney
• Course: 300905
• Professor: anonymous

Document Summary

Psoriasis has a strong hereditary component, and many genes are associated with it, but it is unclear how those genes work together. Most of the identified genes relate to the immune system, particularly the major histocompatibility complex (mhc) and t cells. Genetic studies are valuable due to their ability to identify molecular mechanisms and pathways for further study and potential medication targets. Classic genome-wide linkage analysis has identified nine loci on different chromosomes associated with psoriasis. They are called psoriasis susceptibility 1 through 9 (psors1 through psors9). Within those loci are genes on pathways that lead to inflammation. Certain variations (mutations) of those genes are commonly found in psoriasis. Genome-wide association scans have identified other genes that are altered to characteristic variants in psoriasis. Some of these genes express inflammatory signal proteins, which affect cells in the immune system that are also involved in psoriasis. Some of these genes are also involved in other autoimmune diseases.