400981 Lecture Notes - Lecture 22: Adrenocortical Adenoma, Benign Tumor, Pituitary Adenoma

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A benign tumour is a mass of cells that lacks the ability to either invade neighbouring tissue or metastisize (spread throughout the body). When removed, benign tumours usually do not grow back, whereas malignant tumours sometimes do. Unlike most benign tumours elsewhere in the body, benign tumours can be life threatening. Benign tumours generally have a slower growth rate than malignant tumours and the tumour cells are usually more differentiated (cells have more normal features). They are typically surrounded by an outer surface (fibrous sheath of connective tissue) or stay contained within the epithelium. Common examples of benign tumours include moles and uterine fibroids. Although benign tumours will not metastasize or locally invade tissues, some types may still produce negative health effects. The growth of benign tumours produces a mass effect that can compress tissues and may cause nerve damage, reduction of blood flow to an area of the body (ischaemia), tissue death (necrosis) and organ damage.

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