401002 Lecture Notes - Lecture 8: Enteric Nervous System, Central Nervous System, Afferent Nerve Fiber

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It normally communicates with the central nervous system (cns) through the parasympathetic (and sympathetic nervous systems. However, vertebrate studies show that when the vagus nerve is severed, the enteric nervous system continues to function. In vertebrates, the enteric nervous system includes efferent neurons, afferent neurons, and interneurons, all of which make the enteric nervous system capable of carrying reflexes in the absence of cns input. The sensory neurons report on mechanical and chemical conditions. Through intestinal muscles, the motor neurons control peristalsis and churning of intestinal contents. The enteric nervous system also makes use of more than 30 neurotransmitters, most of which are identical to the ones found in cns, such as acetylcholine, dopamine, and serotonin. More than 90% of the body"s serotonin lies in the gut, as well as about 50% of the body"s dopamine; the dual function of these neurotransmitters is an active part of gut brain research.

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