IMED1002 Lecture Notes - Lecture 10: Zygote, Nonsense Mutation, Frameshift Mutation
15 Aug 2018
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Lecture #26: gene expression control ii: 7th may 2018: Understanding that transcriptional regulators trigger transcription through alteration of chromatin structure. Be able to describe the histone code and the importance of retaining the code. Understand how histone modification (acetylation) impacts on chromatin structure. Understand the process of dna methylation and the affect on gene expression. Understand that mrna stability, localisation and post-translational control are mechanisms of controlling gene expression. Be able to describe process of eukaryotic mrna decay. Understand control of gene expression occurs through translational initiation. Eukaryotic transcription activators direct modification of local chromatin structure: Tfs and rna polymerase are unable on their own to assemble on a promoter that is packaged in nucleosomes. Transcription activators promote transcription by triggering changes in chromatin structure- dna accessible. Covalent histone modification, nucleosome remodelling, histone replacement. Attract histone modification enzymes, chromatin remodelling complexes. Histones are modified by phosphorylation, acetylation, methylation, ubiquitination. Hence want to retain the histone code.
