IMED2004 Lecture Notes - Lecture 10: Non-Coding Rna, Dna Replication, Lung Cancer
25 Mar 2020
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Document Summary
Chemical entity subject to damage and change and to chemical modification: dna damage. It occurs at a rate of 1000 to 1 000 000 molecular lesions per cell per day. And due to endogenous (normal cell metabolism factors) But sometimes its not important and the effects aren"t major. Impede a cell"s ability to carry out normal function. Lung cancer caused by tobacco smoke: mistakes can occur at many levels, translation error . This can have quite a profound effect in the self: we can split mutations broadly up into 2 categories, somatic: Only affects that cell (every cell in the body that are not reproductive) Mutation is not inherited: transcription error mrna & protein is affected. Dna, rna & protein is affected: germ-line: Can be inherited (permanent: dna damage can be caused by either external or internal factors, external factors examples: Chemical mutagens: dna is damaged, cell has mechanisms in place to detect this.
