IMED2004 Lecture Notes - Lecture 2: Housekeeping Gene, Somatic Cell, Regulatory Sequence
25 Mar 2020
School
Department
Course
Professor
Document Summary
In order to precisely turn on and off the correct sets of genes for each cell type, gene expression is regulated at many levels. Regulation of gene: differential gene expression from the same nuclear repertoire is accomplished by regulation at several levels, at every step there is something regulating it. Some factors influencing gene expression: signals, cell-cell contact, hormones (some have nuclear receptors- translocate into nucleus and act as tfs, morphogens. Many morphogens are transcription factors: transcription factors, proteins which bind to regulatory elements of a gene, control transcription, often synthesised or activated in response to external stimuli (above, 2 main categories: (e. g. hormone binding) Muscle development- it binds to its own promoter. It would turn more of tfs that would turn more of myod on. Activation of myod- so potent that if its too much- it will turn a fibroblast cell into a muscle cell.
