IMED3001 Lecture Notes - Lecture 13: Lipoprotein Lipase, Prospective Cohort Study, Absolute Risk Reduction
26 Mar 2020
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Ldl: (bad: predominantly cholesterol esters, apolipoproteins: b100, hdl: (good, cholesterol esters, apolipoproteins: ai, aii, c"s, d, e. Lp(a) (bad) (ugly: cholesterol esters, apolipoproteins: b100, a, apolipoproteins, a1, activates lecithin cholesterol acyltransferase, aii, activates hepatic lipase, b100 ligand for ldl receptor required for secretion of vldl, b48, assembly and secretion of. Chylomicrons: does not bind to the ldlr, ci, activates lcat, cii. Ldl cholesterol causes ascvd: evidence from separate meta-analyses of over. Lowering ldl-c in individuals at high cardiovascular risk earlier rather than later appears advisable, especially in those with familial hypercholesterolaemia. Exogenous lipoprotein transport: chylomicrons, carry dietary lipids, have apolipoproteins: b48, c"s and e, chylomicron remnant (ugly, vldl: (bad, carry hepatic lipids, apolipoproteins b100, c"s and e. Ldl can be oxidative modification via arterial wall macrophage. Ldlr are upregulated, thus ldl particles are removed: apo b, non hdl-c and ldl-c are reduced. Lifestyle: diet, cvd health, mediterranean diet- supplemented with extra virgin olive oil or nuts, lower cholesterol:
