KINE 2P20 Lecture Notes - Lecture 8: Collagen, Pyruvic Acid, Protein Digestibility Corrected Amino Acid Score
9 May 2018
School
Department
Course
Professor
Nutrition 2P20
Shape Determines Function
- Denaturation and mutation can affect function
- If the shape is altered the function may be disrupted
Denaturation
- Temperature of pH changes can affect function
Mutation
- Alterations in base sequence of genes
- Alters 1 degree structures which in turn alters 2, 3, and 4 degree structures, which
changes function
▪ Sickle cell
Amino Acid Pool: all of amino acids in body tissues and fluids that are readily available for use
by the body
Protein Turnover: the continuous synthesis and breakdown of body proteins
- Balance between synthesis and breakdown
- Continuous process
- Temporal fluctuations
▪ Eating, exercising, sleeping
- Occurs at different rates in different tissues
▪ Proteins with a regulatory function (enzymes) or that act as signals
(hormones) are FAST (hours or days)
▪ Structural Proteins (collagen or contractile proteins) are SLOWER (days,
weeks or months)
Protein Synthesis
- Gene – transcription – translation – protein
Energy Production from Protein
- Deamination
- 2c AA’s form Acetyl-CoA
- 3c AA’s form pyruvate
▪ can be used as energy for gluconeogenesis
Excretion
- After deamination, amine group = ammonia (toxic)
- Liver turns ammonia into urea
- Excreted by kidneys as urine
▪ Need water to excrete
▪ If no increased water intake, is taken from body water
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Document Summary
If the shape is altered the function may be disrupted. Temperature of ph changes can affect function. Alters 1 degree structures which in turn alters 2, 3, and 4 degree structures, which changes function: sickle cell. Amino acid pool: all of amino acids in body tissues and fluids that are readily available for use by the body. Protein turnover: the continuous synthesis and breakdown of body proteins. Occurs at different rates in different tissues: proteins with a regulatory function (enzymes) or that act as signals (hormones) are fast (hours or days, structural proteins (collagen or contractile proteins) are slower (days, weeks or months) Gene transcription translation protein. 3c aa"s form pyruvate: can be used as energy for gluconeogenesis. After deamination, amine group = ammonia (toxic) Liver turns ammonia into urea: need water to excrete. If no increased water intake, is taken from body water. 24h urine is a measure of whole-body protein balance.
