BIOL 462 Lecture 5: BIOL 462 Lecture 5 notes
18 Feb 2019
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Biol 462 lecture 5 notes: receptor recognition and signaling part i. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals can be generated by the binding of a ligand to its complementary, cell-bound receptor. The ligand may be a soluble molecule/peptide/carbohydrate/ lipid. The ligand may travel long distances from its entry point via the bloodstream or lymph before it reaches receptive cells. Receptors bind to ligands using the full range of noncovalent bonding interactions (ionic, h bonds, van der waals, hydrophobic) For signaling to occur the bonds must be sufficiently strong to hold the ligand/receptor in close proximity for long enough to initiate downstream events. In b- and t- cell signaling, activating interactions also require receptor clustering. Ligand-receptor binding induces molecular change in the receptor: conformation, dimerization/clustering, membrane relocation, changes in membrane local composition (e. g. , lipid rafts, covalent modification.
