BIOL 462 Lecture Notes - Lecture 13: Memory T Cell, Cytokine Receptor, Signal 1

• School: Concordia University
• Department: Biology
• Course: BIOL 462
• Professor: Dr. Chiara Gamberi

Document Summary

Biol 462 lecture 13 notes t cell activation. 3 signals are required to activate na ve t cell: tcr signaling, costimulatory interaction, cytokine. Na ve t cell activation in the lymphoid organs produces effector and memory t cells. Cytokines are produced by apcs and local cells. Activation of a na ve t cell in a secondary lymphoid organ results in the generatin of effector and memory t cells. Activation requires several receptor- ligand interactions between the t cell and a dendritic cell, as well as signals through cytokines produced by the apc. Effector cd4+ t cells become helper t cells and secrete cytokines that enhance the activity of other immune cells. Effector cd8+ t cells are cytotoxic t cells that kill infected cells. Pic: a successful t-cell/dendritic-cell interaction results in the organization of signaling molecules into an immune synapse. Signal 1: tcr + mhc + cd4 or cd8. Signal 2: co-stimulatory e. g. , cd28 > cd80/86 (na ve),