PHYL 1010Y Lecture Notes - Lecture 2: Heat Stroke, Vasoconstriction, Bone Resorption
18 Apr 2015
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If glucose levels are within normal range - used by body as primary o energy source (excess glucose stored as glycogen or stored as fat) If plasma glucose levels decrease - body breaks down glycogen to glucose o via glycogenolysis (aa and glycerol converted to glucose via gluconeogenesis) Therefore fat becomes the major energy source: describe the metabolic effects of insulin and the factors that exert control over insulin secretion. Lowers plasma glucose concentration by increasing glycogen synthesis, o aerobic metabolism of glucose and protein/triglyceride synthesis. Feedforward effects of gi hormones (glp-1 and gip) Parasympathetic activity (increase in gi tract and pancreas following a o o o o meal) o. Factors controlling: decreased plasma glucose (<100 mg/dl, decreased insulin levels, stimulated by plasma aa. Target receptors: membrane receptor with tyrosine kinase activity which initiates complex intracellular cascades; pathways with insulin-receptor substrates. Glucagon, ne/e, cortisol metabolize liver glycogen & raise plasma. Cortisol, e/ne promote conversion of triglycerides to glycerol + o.
