BIOL 300 Lecture Notes - Lecture 10: Fibroblast, Histone Acetyltransferase, Nucleosome
5 Mar 2018
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Lecture 10 noncoding rna and transcription: long non-coding rna (lncrna, x-inactivation in mammals, male specific lethal (msl) complex in drosophila, short non-coding rna (sirna, heterochromatin formation in centromere of fission yeast, transposon silencing in drosophila. Dosage compensation: the difference in the number of x chromosome between males and females is compensated at the level of transcription. In mammals: in females, one of the x chromosome gets completely shut down: they do this by regulating transcription. However it doesn"t affect transcription of any other chromosome include the other x chromosome. It will be expressed from its locus and passively march along the x chromosome in a linear way: you can see a bell curve in the abundance of xist, with the highest point at the original locus, 2. 2: they realized the peaks resembles the pattern they discovered peaks of proximity in. Integration of xist into chromosome 21 in trisomic pluripotent stem cells.
