MIMM 214 Lecture Notes - Lecture 30: Immunoglobulin Class Switching, Fc Receptor, Fragment Crystallizable Region
17 Apr 2017
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Document Summary
Dna: double stranded breaks in dna upstream of constant region to be recombined, ds break repair machinery repairs break by cutting out the intervening. Selected region now adjacent to vdj region: productive mrna translation will occur. Function: antibodies mediate the clearance and destruction of pathogen in a variety of ways, each ab isotype has distinct properties and traits that enable it to do so. Their distribution is also distinct depending on their functions. Family of cell surface receptors that bind to the fc portion of igs: expressed on macrophages, granuloctytes, dcs, mast cells, b cells, epithelial cells, bind igs in a class specific manner, e. g. Fc receptors mediate many effector functions of antibodies: fcr signaling the binding antibody must be bound to its antigen in order to induce signaling, crosslinking fcr is important to trigger signaling. Fcrs are involved in mediating many important functions in humoral immunity.
