MIMM 214 Lecture Notes - Lecture 10: C5-Convertase, Complement Membrane Attack Complex, C3B
10 Sep 2018
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2. 5 the complement system recognizes features of microbial surfaces and marks them for destruction by coating them with c3b: preview of initiation mechanisms and outcomes of complement activation, 3 pathways initiated. C3b: c3b is the main effector in complement system, c3a is also a product : is smaller peptide that binds to specific receptors to, c3 cleavage. Complement coating help phagocytes dispose of dying cells: limits triggering an autoimmune response. 2. 8 complement activation is largely confined to the surface on which it is initiated. C4b binding covalently to pathogen surface initiates the innate immunity: c4 cleavage. Is catalyzes by a ficolin, mbl bound to a pathogen surface: products can bind to adjacent proteins/carbs on pathogen surface. Bonded coat to signal its pathogen from phagocytes. Next step in complement cascade after initiation: c5 convertase generation, c5 convertase is in the same family as c3, c4, alpha-2-macroglobulin family and.
