MIMM 214 Lecture Notes - Lecture 9: Rubella Virus, Measles, Epithelium
5 Jan 2019
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Document Summary
23 yr old female on third month of pregnancy. Develops rash fever and swollen glands all over the body. Rash disappears with pressure - caused by blood (accumulation) As the physician, you suspect she has rubella (german measles) Injury mediated by toxins produced by the actual pathogen, microbe binds a receptor on the surface of epithelial cell, immune response against the virus. Recognition of different forms of nucleic acids (tlr. Before the virus is intracellular, it is extracellular for some time period; thus, the complement activation system is important via the recognition of viral surface components which activates the pathway (components of the capsid, envelope etc. ) Antigen presenting cells (dendritic cell & macrophages) present the antigen molecules from the virus and activates lymphocytes of adaptive immune response - proliferation & differentiation (b cells & t cells) Painful lymph nodes = normal immune response (because pro-inflammatory response accompanies)
