PHAR 562 Lecture Notes - Lecture 10: Substantia Nigra, Lysine, Cell Membrane
8 Sep 2017
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Document Summary
Topics: voltage gated ion channel diversity, voltage-gated calcium channels have many diverse family membranes, voltage-gated potassium channels have different membrane topologies, structural basis of ion permeation. Increased firing and upregulation of channels at the gene level in different parts of the reward pathway, which reinforces the desire to get the drug: primary afferent pain sometimes involves upregulation of ca channels. Inward rectifiers k+ channels that are blocked by polyamines: two transmembrane regions instead of six. Drug targets and cns disease: drugs target different parts of the channel, outer-pore blocking, gating modifier toxins, e. g. hanatoxin that binds the s4 region and interacts with s3, other gating modifiers underneath the pore. Inner pore blockers: disinactivators prevent auxiliary subunits exerting their effect, k+ channels are involved in many cns diseases. Increased firing in pain, pd, anxiety, schizophrenia, seizures, etc: the main role of k+ channels is to stabilise membrane potential, need a channel activator.
