PHGY 209 Lecture Notes - Lecture 3: Choroid Plexus, Phantom Pain, Cerebral Cortex
12 Jan 2018
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Help regulate what comes out of blood to the extracellular fluid of the brain, you don"t want just anything coming into the cns. Bbb: endothelial cells that normally line the capillaries, tight junction formed in between the epithelial cells prevents stuff from the getting from the. Ecf into the cns as there is this tight junction. Clinical problem: if you want a drug to get into the cns it has to pass across the bbb. It can diffuse across endothelial cells has to be lipid soluble; co2, o2, Ions: don"t cross good, proteins are prohibited from crossing bbb unless they hitch a ride with an active transport mechanism. Glucose does not diffuse easily, has to be actively moved through the bbb. The drug needs to be lipid soluble or hitch a ride on the active transport mechanisms. Csf creation, won"t let anything else go into the ventricles only csf.
