BIOCHEM 2EE3 Lecture 14: Module 10A
8 Dec 2017
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Document Summary
1. 3 overview of the breakdown of glucose to co2. The first phase of glucose metabolism is glycolysis and occurs in the cytosol. In glycolysis, glucose is broken down from a six-carbon compound to two three-carbon compounds, called pyruvate. The net output of glycolysis is the generation of two molecules of nadh and two molecules of atp. In this module, we will look at the oxidation of the pyruvate, that was generated from glycolysis, to carbon dioxide. The oxidation of pyruvate occurs inside the mitochondrion and occurs in two stages. First, the conversion of the three-carbon pyruvate to a two-carbon molecule of acetylcoa, followed by the oxidation of acetylcoa to carbon dioxide through the citric acid cycle. The oxidation of pyruvate to acetylcoa is catalyzed by the enzyme, pyruvate dehydrogenase (pdh is the abbreviation for the name of this enzyme), which is located in the mitochondrion.
