BIOCHEM 3H03 Lecture Notes - Lecture 3: Osmoreceptor, Vasoconstriction, Acidosis
5 Feb 2017
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Molarity: number of moles/l solution: 1 m naoh solution. Mw of naoh is 40g/mol add 40g to 1l to make 1 m naoh. Molality: number of moles of solute per kg solvent (water) If molecule ionizes, each ion contributes to osmolarity. 1 mmol glucose in 1 l = 1 mosm/l. 1 mmol cacl2 in 1 l = 3 mosm/l. Osmolarity vs osmolality: for a simple solution, there is no significant difference, for plasma, there is a significant difference. All body fluids are aqueous: transport of nutrients and removal of waste, chemical reactions of the body are conducted in water based buffer. Volume, constituents and concentration must be maintained to support life all factors are interconnected. Intracellular compartment = 2/3 of total body water. Extracellular compartment = 1/3: major divisions plasma (1/4 = 8-10% of tbw), interstitial , minor division transcellular (csf, intraocular, pleural, peritoneal, synovial fluid, digestive secretions) Under pathological conditions this can represent a large portion of extracellular fluid.
