BIOLOGY 1A03 Lecture Notes - Lecture 6: Antibody, Interleukin 1 Beta, Cd14

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Lovaye Kajiura

Document Summary

Marco is required for tlr2- and nod2-mediated responses for. Streptococcus pneumoniae, a common human virus, primarily found in children causes about one million deaths each year. The source of these deaths is the outcome of a pneumococcal pneumonia pathogen which spreads from the nasopharynx into the lungs. Regardless, of antibiotic usage and polysaccharide vaccines the bacterium continues to cause challenges, such as antibiotic resistance. Initially, pneumococcal colonization occurs through a vigorous and ineffective neutrophil response. This happens when monocytes are brought from the blood into the nasal spaces where they alter into macrophages that can essentially phagocyte and kill bacteria. The monocytes are attracted by chemokine ccl2 which recognizes the nucleotide-binding oligomerization domain-containing (nod2). Scavenger receptor a (sra) and macrophage receptor with collagenous structure (marco) are able to bind with s. pneumoniae through nonopsonic mechanisms. Together, marco and sra can bind and phagocyte s. pneumoniae in the murine pneumonia model.