BIOLOGY 1A03 Lecture Notes - Lecture 4: Post-Translational Modification, Epigenome, Epigenomics

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Lovaye Kajiura

Document Summary

Applied lecture epigenetics and gene regulation: signals are detected by cells. A signal is received by a cell. Receptors on eager cell will bind signal. Signal transduction cascade can lead to short term or long term responses in target cell: short term: modify immediate cell processes (ex. metabolism, movement) Can include post translational protein modifications: long term: modification of gene expression and/or development, levels of gene expression regulation. Chromatin, transcription, rna processing, rna stability, translation, post translational modification. Epigenome: genome is inherited, epigenome can be altered, epigenetics: above the genome , chemical dna modifications that occur along genome that change gene activity without altering. Dna sequence epigenetics processes are essential for normal development, cell differentiation, and are increasingly being recognized as being involved in human diseases: epigenetic mechanisms. Packaging of dna around nucleosomes: epigenomics: studying epigenetic modifications across an individuals entire genome. Epigenetic mechanisms and health: epigenetics mechanisms are affected by: