BIOLOGY 2B03 Lecture Notes - Lecture 6: Pyruvic Acid, Cardiac Muscle, Decoy
5 Dec 2017
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Document Summary
G-protein and activation of an effector protein, adenylyl cyclase, that modulates the cytosolic concentration of a secondary messenger, camp. Increased camp- will impact the relase of stored energy required for the fight-or-flight response: the fast response requires the activation of an enzyme, while the slow response will activate transcription. In the liver glycolysis releases glucose from glycogen. In the adipose tissue lipolysis leads to the breakdown of fatty acids. It increases the intercellular concentration of the secondary messenger, cyclic amp: adenylyl cyclase is the effector enzyme, hydrolysis of gtp to gdp inactivates gs alpha and it dissociates from adenylyl cyclase. In the absence of g-protein binding the adenylyl cyclase is inactive. In the absence of active adenylyl cyclase there are ubiquitous cytosolic enzymes that decrease the concentration of cyclic amp: only by maintaining an active adenylyl cyclase through receptor activation can the cytosolic concentration of camp stay high.
