BIOLOGY 2B03 Lecture Notes - Lecture 9: Spindle Apparatus, Cyclin B, G1 Phase

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27 Apr 2016
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G2: chromosome condensation; nuclear envelope breakdown; chromosome segregation. Mitosis: sister chromatids are replicated and separated into two daughter cells. Once cells differnentiate, they cannot undergo cell division (muscle cell, rbc, skin cell, neuron, adipose cell ) Cells enter g0 phase of inactivity before reentering the cell cycle. Interphase (g1 s g2): cell prepares for mitosis = chromosomes and proteins. Prometaphase: chromosomes are fully condense; chromosomes attach to. Prophase: chromosomes condense; centrosomes move to opposite sides of the. 1) are replicated in s-phase; centrisomes are duplicated in g1 and s phase. 2) cell, mitotic spindle fibres start to form; nuclear envelope break dissolves; endomembranes breakdown into small vesicles. 3) bipolar microtubules spindle at their centromere; kinetochore proteins assemble at the centromere to mediate the association of the + ends of spindle microtubule. 4) pole of the mitotic spindle = bipolar attachment; chromosomes align in the middle of the mitotic spindle = equator of the spindle.

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